These neurotransmitters regulate mood, behavior, and cognitive function. This blog explores how your genetic variants impact mental well-being and provides actionable strategies for balance.

The Role of Methylation in Mental Health

Methylation influences the production and breakdown of neurotransmitters like dopamine, serotonin, and norepinephrine. If methylation pathways are impaired, it can lead to mood disorders, including anxiety, depression, and ADHD.

Key Genes Involved

• COMT (Catechol-O-Methyltransferase): Breaks down dopamine and estrogen, affecting stress response and mood.
• MTHFR: Regulates folate, essential for serotonin production.
• CBS: Balances sulfur metabolism, impacting neurotransmitter levels.

Relevant SNPs

• COMT Val158Met (rs4680)
• MTHFR C677T (rs1801133)
• CBS C699T (rs234706)

How to Support Mental Health Through Lifestyle Changes

1. Nutritional Support

Methylated B vitamins (such as 5-MTHF and methylcobalamin) can help individuals with MTHFR variants maintain optimal neurotransmitter levels.
Include foods rich in omega-3 fatty acids (like chia seeds, flaxseed, and walnuts) to support brain health.

2. Stress Management Techniques

Practices such as yoga, meditation, and breathing exercises reduce stress and promote balanced dopamine levels.
Individuals with COMT variants may need additional strategies to prevent overactive dopamine breakdown during stressful situations.

3. Exercise for Neurotransmitter Balance

Aerobic exercise boosts serotonin and endorphin production, which can help counteract depressive symptoms.

Conclusion
Your genetic makeup has a significant impact on your mental health, but with personalized strategies from Geneus DNA, you can take control. With insights into your methylation status and targeted lifestyle changes, you can achieve emotional well-being.

Reference

• Early Life Nutrition and Mental Health: The Role of DNA Methylation
• National Institute of Mental Health (NIMH)