However, genetic variants like MTHFR, MTR, and BHMT can impair your ability to process homocysteine effectively, raising health concerns. Understanding your genetic predisposition can empower you to make the right lifestyle adjustments for heart health.

What is Homocysteine?

Homocysteine is a byproduct of methionine metabolism, a key process in the methylation cycle. In healthy individuals, excess homocysteine is converted into either methionine or cysteine through enzymatic reactions. If this process is disrupted, homocysteine builds up in the bloodstream, damaging the arteries.

Genes Involved in Homocysteine Regulation

• MTHFR: Converts folate into 5-MTHF, essential for homocysteine processing.
• MTR and MTRR: Support methionine production by recycling homocysteine.
• BHMT: Uses betaine to convert homocysteine to methionine, preventing its accumulation.

Common SNPs Related to Homocysteine Levels

• MTHFR C677T (rs1801133) and A1298C (rs1801131)
• MTR A2756G (rs1805087)
• MTRR A66G (rs1801394)
• BHMT rs651852
• SHMT C1420T (rs1979277)
• CBS C699T (rs234706)
• CTH rs1021737

Practical Tips to Lower Homocysteine

1. Eat Folate-Rich Foods: Spinach, broccoli, and lentils help maintain healthy homocysteine levels.
2. Take Methylated B Vitamins: Use 5-MTHF and methylcobalamin for effective absorption.
3. Exercise Regularly: Physical activity improves blood vessel health.
4. Get Tested: Genetic testing can help you understand your risk and personalize your treatment plan.

Conclusion
Your DNA holds the key to better heart health. At Geneus DNA, we analyze the genes involved in the methylation cycle that directly influence homocysteine levels—a critical factor for cardiovascular health. With personalized insights, you can take practical steps to support your heart and overall wellness, all based on what your genetics reveal about you.

Reference

•  American Heart Association’s article on homocysteine and cardiovascular disease.